Jasper Dingemanse Selected Research

Endothelins (Endothelin)

1/2019	Single- and multiple-dose tolerability, safety, pharmacokinetics, and pharmacodynamics of the dual endothelin receptor antagonist aprocitentan in healthy adult and elderly subjects.
10/2014	Pharmacokinetic-pharmacodynamic relationships of macitentan, a new endothelin receptor antagonist, after multiple dosing in healthy Korean subjects.
1/2008	Lack of renal improvement with nonselective endothelin antagonism with tezosentan in type 2 hepatorenal syndrome.
2/2005	Effects of the endothelin receptor antagonist bosentan on hemodynamics, symptoms and functional capacity in Japanese patients with severe pulmonary hypertension.
8/2004	The hemodynamic and neurohormonal effects of low doses of tezosentan (an endothelin A/B receptor antagonist) in patients with acute heart failure.

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Jasper Dingemanse Research Topics

Disease

37	Pulmonary Arterial Hypertension 02/2018 - 04/2003
21	Sleep Initiation and Maintenance Disorders (Insomnia) 05/2024 - 06/2013
12	Hypertension (High Blood Pressure) 02/2024 - 01/2013
12	Headache (Headaches) 11/2022 - 04/2002
9	Body Weight (Weight, Body) 01/2023 - 04/2003
7	Sleepiness 10/2021 - 02/2007
6	Myocardial Infarction 09/2023 - 01/2020
6	Vomiting 01/2021 - 07/2002
6	Nausea 01/2020 - 07/2002
5	Autoimmune Diseases (Autoimmune Disease) 01/2023 - 02/2015
5	Multiple Sclerosis 12/2021 - 05/2015
4	Systemic Lupus Erythematosus (Libman-Sacks Disease) 11/2022 - 01/2020
4	Fibrosis (Cirrhosis) 10/2021 - 01/2008
4	Sleep Wake Disorders 10/2021 - 04/2014
3	Breast Neoplasms (Breast Cancer) 11/2023 - 11/2020
3	Hemorrhage 07/2023 - 01/2019
3	Edema (Dropsy) 01/2021 - 03/2014
3	Fatigue 12/2020 - 01/2012
3	Fabry Disease (Fabry's Disease) 10/2020 - 11/2017
3	Diarrhea 06/2017 - 08/2009
3	Asthma (Bronchial Asthma) 01/2015 - 12/2013
3	Allergic Rhinitis 01/2015 - 12/2013
3	Type 2 Diabetes Mellitus (MODY) 10/2013 - 10/2009
3	Cystic Fibrosis (Mucoviscidosis) 01/2013 - 02/2012
3	Heart Failure 08/2004 - 04/2002
2	Cognitive Dysfunction 12/2023 - 04/2014
2	Coronary Artery Disease (Coronary Atherosclerosis) 07/2023 - 01/2020
2	Obstructive Sleep Apnea 01/2022 - 11/2021
2	Liver Cirrhosis (Hepatic Cirrhosis) 10/2021 - 04/2009
2	Anxiety Disorders (Anxiety Disorder) 01/2020 - 01/2003
2	Hypotension (Low Blood Pressure) 01/2020 - 01/2008
2	Psoriasis (Pustulosis Palmaris et Plantaris) 02/2018 - 02/2015
2	Diabetic Nephropathies (Diabetic Nephropathy) 05/2010 - 09/2006
2	Pulmonary Hypertension 02/2005 - 05/2004
1	Ataxia (Dyssynergia) 12/2023
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 09/2023
1	Gastroenteritis 11/2022
1	Apnea 01/2022
1	Acute Lung Injury 12/2021
1	Chronic Obstructive Pulmonary Disease (COPD) 01/2021
1	Weight Gain 01/2021
1	Dizziness (Lightheadedness) 12/2020

Drug/Important Bio-Agent (IBA)

29	Endothelin Receptor AntagonistsIBA 02/2024 - 04/2002
23	Orexin Receptor AntagonistsIBA 05/2024 - 01/2011
20	daridorexantIBA 05/2024 - 01/2019
18	Bosentan (Tracleer)FDA Link 04/2017 - 04/2002
14	macitentanIBA 01/2018 - 03/2012
9	aprocitentanIBA 02/2024 - 01/2019
8	Sphingosine-1-Phosphate ReceptorsIBA 01/2020 - 12/2013
8	ponesimodIBA 02/2018 - 12/2013
7	selexipagIBA 02/2018 - 01/2014
7	almorexantIBA 05/2014 - 01/2011
6	Purinergic P2Y Receptor AntagonistsIBA 09/2023 - 01/2020
6	selatogrelIBA 09/2023 - 01/2020
6	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 11/2022 - 12/2013
6	Epoprostenol (Prostacyclin)FDA LinkGeneric 06/2017 - 04/2003
5	EnzymesIBA 07/2023 - 01/2010
5	Endothelins (Endothelin)IBA 01/2019 - 08/2004
5	Epoprostenol ReceptorsIBA 02/2018 - 01/2014
5	miglustat (Zavesca)FDA Link 01/2013 - 08/2009
5	tezosentanIBA 05/2012 - 04/2002
4	OrexinsIBA 12/2023 - 02/2007
4	cenerimodIBA 11/2022 - 01/2020
4	clazosentanIBA 01/2021 - 01/2019
4	GlycosphingolipidsIBA 10/2020 - 05/2012
3	Proteins (Proteins, Gene)FDA Link 11/2023 - 11/2020
3	migalastatIBA 10/2020 - 11/2017
3	ceramide glucosyltransferaseIBA 10/2020 - 11/2017
3	Endothelin A ReceptorIBA 01/2020 - 01/2019
3	ProstaglandinsIBA 02/2018 - 01/2015
3	2- (2- (1- naphthoyl)- 8- fluoro- 3,4- dihydro- 1H- pyrido(4,3- b)indol- 5(2H)- yl)acetic acidIBA 01/2017 - 12/2013
3	Insulin (Novolin)FDA Link 10/2013 - 10/2009
3	Glucose (Dextrose)FDA LinkGeneric 10/2013 - 10/2009
2	Rosuvastatin Calcium (Crestor)FDA Link 11/2023 - 11/2020
2	Complement System Proteins (Complement)IBA 01/2023 - 01/2020
2	CreatinineIBA 11/2021 - 01/2008
2	Warfarin (Coumadin)FDA LinkGeneric 05/2016 - 05/2002
2	ambrisentan FDA Link 03/2015 - 03/2014
2	Formyl Peptide Receptors (Formyl Peptide Receptor)IBA 12/2014 - 12/2013
2	MK-1597IBA 12/2013 - 10/2013
2	Endothelin Receptors (Endothelin Receptor)IBA 08/2013 - 01/2008
2	AlbuminsIBA 05/2010 - 09/2006
2	1- (2- (4- benzyl- 4- hydroxypiperidin- 1- yl)ethyl)- 3- (2- methylquinolin- 4- yl)ureaIBA 05/2010 - 10/2009
2	Sildenafil Citrate (Viagra)FDA Link 11/2009 - 01/2008
2	urotensin IIIBA 10/2009 - 09/2006
2	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 05/2008 - 01/2008
2	Endothelin-1 (Endothelin 1)IBA 01/2008 - 05/2004
2	Transaminases (Aminotransferases)IBA 01/2004 - 04/2002
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 11/2023
1	Dabigatran FDA Link 11/2023
1	CXC ChemokinesIBA 09/2023
1	Factor VaIBA 01/2023
1	Alkaline PhosphataseIBA 01/2023
1	ACT-1004-1239IBA 12/2021
1	Citalopram FDA LinkGeneric 10/2021
1	SodiumIBA 01/2021

Therapy/Procedure

8	Therapeutics 12/2023 - 09/2006
3	Self Administration (Administration, Self) 09/2023 - 01/2021
1	Drug Therapy (Chemotherapy) 12/2023
1	Intravenous Administration 07/2023